As for the transmission tunnel, the larger one used on the 435 and 4-wheel drives is a separate piece that bolts to the floor over an opening cut into the floor. 2 wheel drives don't have the opening already cut out, although the creases where the cut out is are already there. In coverting my 2-wheel drive into a 4, I still have to cut the hole into the cab floor.
The 435 does have the shift lever protrude out the top, but the shift lever is contorted in such a manner that it's not an issue as with my D300. One thing that may or may not be an issue is the length of the drive shaft. Conventional cab 2 wheel drive automatic transmissions have a long extension housing at the rear, which allows the use of a single, long, large diameter (4 inch?) drive shaft. I believe the extended cab automatic models used a tranny with a short extension and a smaller diameter double drive shaft with a carrier bearing between. The NP435 is shorter in length, which will likely need a double drive shaft unless you have a short wheelbase conventional cab, which may make it possible to use a single drive shaft. Can't say for sure about that.
Incidentlly, the 1970's and early 80s (at least) 4 wheel drives used short extension automatic transmissions, which made room for the transfer case.